甄宇红，博士，教授，硕士研究生导师，药物化学教研室主任。1992年毕业于华东理工大学化学制药专业，1997年获大连理工大学精细化工专业硕士学位，2008年获大连理工大学环境与生命学院生物化工专业博士学位。2009年至2010年于日本金沢大学药学院进修，2010.6-2012.6大连赛姆生物技术公司博士后。主持省市级科研课题7项，参与国家级课题多项。发表论文50余篇，其中SCI收录20余篇；获得大连市科技进步奖2项，辽宁省科技进步奖2项；获授权发明专利2项。参加编写教材20部，其中规划教材13部。现受聘为日本金沢大学合作教授。
研究方向
1、具有抗肿瘤活性的天然产物的结构改造；
2、靶向性的基因和药物载体的构建及抗肿瘤作用研究。
在研项目
1.7-O-香叶基槲皮素与miRNA协同逆转乳腺癌细胞MCF-7/adr对阿霉素的耐药作用及机制研究。辽宁省自然科学基金项目，2017.05-2019.04，在研，负责人。
2.阳离子脂质体运载烃基槲皮素及IGF-1R-siRNA对非小细胞肺癌的作用研究。辽宁省自然科学基金项目， 2016.05-2018.04，在研，执行负责人。
3.基于iRGD类脂靶向载体的可控构建及其siRNA转运研究。国家自然科学基金面上项目，2018.01-2021.12，在研，第二完成人。
4.有机分子催化环酯类开环可控聚合机制的理论研究。国家自然科学基金青年基金项目，2018.01-2020.12，在研，第二完成人。
代表性论文
1. Yinan Zhao, An Liu, Yanyan Du, Yingnan Cao, Enxia Zhang, Quan Zhou, Hua Hai, Yuhong Zhen*, Shubiao Zhang*. Effects of sucrose ester structures on liposome mediated gene delivery. Acta Biomaterialia,2018,72:278-286.
2.Yinan zhao, Yongze Piao, Chuanmin Zhang, Yameng Jiang, An Liu, Shaohui Cui, Defu Zhi, Yuhong Zhen*, Shubiao Zhang*. Replacement of quaternary ammonium head groups by tri-ornithine in cationic lipids for the improvement of gene delivery in vitro and in vivo. Journal of Materials Chemistry B, 2017, 5: 7963-7973.
3. Huaying Shi, Jie Zhu, Boyang Zou, Lei Shi, Linying Du, Yayi Long, Huaxin Wang, Hong Xu, Yuhong Zhen*, Lidan Sun*. Effects of specific egg yolk immunoglobulin on pan-drug-resistant Acinetobacter baumannii. Biomedicine & Pharmacotherapy, 2017, 95: 1734-1742.
4. EnxiaWang, Boyang Zou, Lei Shi, Linying Du, Yanyan Zhu,Yameng Jiang, Xiaodong Ma, Xiaohui Kang, Changyuan Wang, Yuhong Zhen*, Lidan Sun*. 7-O-geranylquercetin-induced autophagy contributes to apoptosis via ROS generation in human non-small cell lung cancer cells. Life Sciences, 2017, 180:102-113. IF 3.234
5.Yanyan Zhu, Yameng Jiang, Lei Shi, Linying Du, Xiaodong Xu, Enxia Wang,Yong Sun, Xin Guo, Boyang Zou, Huaxin Wang, Changyuan Wang, Lidan Sun*, Yuhong Zhen*. 7-O-Geranylquercetin induces apoptosis in gastric cancer cells via ROS-MAPK mediated mitochondrial signaling pathway activation. Biomedicine & Pharmacotherapy, 2017, 87: 527-538.
6. Yinan Zhao, Jie Zhu, Hengjun Zhou, Xin Guo, Tian Tian, Shaohui Cui,Yuhong Zhen*, Shubiao Zhang*, Yuhong Xu. Sucrose ester based cationic liposomes as effective non-viral genevectors for gene delivery. Colloids and Surfaces B: Biointerfaces, 2016, 145:454-461. 3.997
7. Xinran Bao, Han Liao, Jiao Qu Yong Sun, Xin Guo, Enxia Wang, Yuhong Zhen*. Synthesis, characterization and cytotoxicity of alkylated quercetin derivatives. Iranian Journal of Pharmaceutical Research, 2016, 15 (3): 329-335 1.372
8. Han Liao, Xinran Bao, Jie Zhu, Jiao Qu, Yong Sun, Xiaodong Ma, Enxia Wang,Xin Guo, Qi Kang, Yuhong Zhen*. O-Alkylated derivatives of quercetin induce apoptosis of MCF-7 cells via a caspase-independent mitochondrial pathway. Chemico-Biological Interactions, 2015, 242: 91-98.
9.Yong Sun, Yiheng Yang, Lifen Wang, Li Lv, Jie Zhu, Wenqi Han, Enxia Wang, Xin Guo, Yuhong Zhen*. Highly sensitive detection of cancer antigen human epidermal growth factor receptor 2 using novel chicken egg yolk immunoglobulin. Biologicals, 2015, 43 (3):165-170.
10.Yong Sun, Xue Feng, Jiao Qu, Wenqi Han, Zi Liu, Xu Li, Ming Zou, Yuhong Zhen*, Jie Zhu*. Expression and characterization of the extracellular domain of human HER2 from Escherichia coli, and production of polyclonal antibodies against the recombinant proteins. Applied Biochemistry and Biotechnology, 2015, 176(4):1029-1043.
招生专业
药物化学、药剂学、药理学
联系方式
zhenyhwaner@aliyun.com
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