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姚继红教授简介

 姚继红,教授1988年毕业于中国医科大学临床医疗本科,1988-1991年在大连医科大学获得药理学硕士。2001年获得生物化学专业博士学位。曾公派到美国、日本研修分子药理学和生物化学与分子生物学。现任大连医科大学药教授,博士研究生导师,药学院副院长。

多年从事肝脏疾病分子药理学的研究。近五年主持国家自然基金面上项目4,在国际知名杂志Cell Death Differ(2019, IF 10.717)Redox Biology2022IF 10.787等以通讯作者发表50余篇高水平SCI文章,发表文章进入ESI高被引论文论文曾作为国际一流期刊封面文章。相关研究获国际权威专家高度评价,其学术观点被同行学者系列引用,极大推动了国内外肝脏疾病的研究发展。以第一完成人获辽宁省科技进步二等奖大连市科技进步一等奖辽宁医学科技奖二等奖。“科技兴辽”特聘教授、辽宁省优秀科技工作者、辽宁省首届优秀研究生指导教师、省优秀博士论文指导教师、省教学名师和省优秀教师等荣誉称号。

近五年主持的国家课题(2018-2023):

1.国家自然科学基金面上项目:鼠尾草酸调控miR-34a/SIRT1-p66shc信号通路抗酒精性肝损伤的分子机制研究 814732662015.1-2018.12)

2. 国家自然科学基金面上项目:p66Shc在肝纤维化发病中的作用及lncRNA-Mical2/miR-203a-3p对其调控研究(81773799,2018.1-2021.12)

3.国家自然科学基金面上项目:circ-CBFB调控p66Shc/OMA1信号轴影响线粒体动力学在对乙酰氨基酚诱导肝损伤中的作用及机制研究(81973381,2020.1-2023.12)

4.国家自然科学基金面上项目circ-SLC9A6编码新型蛋白在非酒精性脂肪肝病中的作用及m6A修饰对其调控的研究 82273993,2023.1-2026.12

 

近五年代表性文章(2018-2022):

2018-2022 年以通讯作者发表JCR 1SCI 论文17篇,全球ESI高被引论文1篇,影响因子10分以上论文5篇。

(1) Sun R, Tian X, Li Y, Zhao Y, Wang Z, Hu Y, Zhang L, Wang Y, Gao D, Zheng S#, Yao J#.The m6A reader YTHDF3-mediated PRDX3 translation alleviates liver fibrosis. Redox Biol. 2022 Aug;54:102378. JCR 1IF:10.787(通讯作者)

(2) Yan R, Chu J, Zhou Y, Shan W, Hu Y, Lin M, Zhao Y, Sun R, Wang Z, Lv L, Wang L, Yao J#, Zhang N#. Ubiquitin-specific protease 22 ameliorates chronic alcohol-associated liver disease by regulating BRD4. Pharmacol Res. 2021, 168:105594. JCR 1IF:10.334(通讯作者)

(3) Wang R, Wang Z, Sun R, Fu R, Sun Y, Zhu M, Geng Y, Gao D, Tian X, Zhao Y#, Yao J#. Activation of TAF9 via Danshensu-Induced Upregulation of HDAC1 Expression Alleviates Non-alcoholic Fatty Liver Disease. Front Pharmacol. 2021, 12:775528. JCR 1IF:5.988(通讯作者)

(4) Wang Y, Zhao Y, Wang Z, Sun R, Zou B, Li R, Liu D, Lin M, Zhou J, Ning S, Tian X#, Yao J#. Peroxiredoxin 3 Inhibits Acetaminophen-Induced Liver Pyroptosis Through the Regulation of Mitochondrial ROS. Front Immunol. 2021, 12:652782. JCR 1IF:8.786(通讯作者)

(5) Sun R, Kang X, Zhao Y, Wang Z, Wang R, Fu R, Li Y, Hu Y, Wang Z, Shan W, Zhou J, Tian X#, Yao J#. Sirtuin 3-mediated deacetylation of acyl-CoA synthetase family member 3 by protocatechuic acid attenuates non-alcoholic fatty liver disease. Br J Pharmacol. 2020, 177(18):4166-4180. JCR 1IF:8.74(通讯作者)

(6) Feng D, Wang Z, Zhao Y, Li Y, Liu D, Chen Z, Ning S, Hu Y, Yao J#, Tian X#. circ-PRKCB acts as a ceRNA to regulate p66Shc-mediated oxidative stress in intestinal ischemia/reperfusion. Theranostics. 2020, 10(23):10680-10696. JCR 1IF:11.556(通讯作者)

(7) Wang Z, Zhao Y, Sun R, Sun Y, Liu D, Lin M, Chen Z, Zhou J, Lv L, Tian X#, Yao J#. circ-CBFB upregulates p66Shc to perturb mitochondrial dynamics in APAP-induced liver injury. Cell Death Dis. 2020, 11(11):953. JCR 1IF:8.469(通讯作者)

(8) Wang Z, Sun R, Wang G, Chen Z, Li Y, Zhao Y, Liu D, Zhao H, Zhang F, Yao J#, Tian X#. SIRT3-mediated deacetylation of PRDX3 alleviates mitochondrial oxidative damage and apoptosis induced by intestinal ischemia/reperfusion injury. Redox Biol. 2020, 28:101343. JCR 1IF:11.799(通讯作者)

(9) Zhou J, Zhao Y, Li Z, Zhu M, Wang Z, Li Y, Xu T, Feng D, Zhang S, Tang F, Yao J#. miR-103a-3p regulates mitophagy in Parkinson's disease through Parkin/Ambra1 signaling. Pharmacol Res. 2020, 160:105197. JCR 1IF:7.658(通讯作者)

(10) Wang Z*, Zhao Y*, Zhao H, Zhou J, Feng D, Tang F, Li Y, Lv L, Chen Z, Ma X, Tian X#, Yao J#. Inhibition of p66Shc Oxidative Signaling via CA-Induced Upregulation of miR-203a-3p Alleviates Liver Fibrosis Progression. Mol Ther Nucleic Acids. 2020, 21:751-763. JCR 1IF:8.886(通讯作者)

(11) Li Y, Feng D, Wang Z, Zhao Y, Sun R, Tian D, Liu D, Zhang F, Ning S, Yao J#, Tian X#. Ischemia-induced ACSL4 activation contributes to ferroptosis-mediated tissue injury in intestinal ischemia/reperfusion. Cell Death Differ. 2019, 26(11):2284-2299. JCR 1IF:10.717(通讯作者)

(12) Zhao Y, Wang Z, Feng D, Zhao H, Lin M, Hu Y, Zhang N, Lv L, Gao Z, Zhai X, Tian X, Yao J#. p66Shc Contributes to Liver Fibrosis through the Regulation of Mitochondrial Reactive Oxygen Species. Theranostics. 2019, 9(5):1510-1522. JCR 1IF:8.579(通讯作者)

(13) Zhu J, Wang R, Xu T, Zhang S, Zhao Y, Li Z, Wang C, Zhou J, Gao D, Hu Y, Tian X#, Yao J#. Salvianolic Acid A Attenuates Endoplasmic Reticulum Stress and Protects Against Cholestasis-Induced Liver Fibrosis via the SIRT1/HSF1 Pathway. Front Pharmacol. 2018, 9:1277. JCR 1IF:3.845(通讯作者)

(14) Zhao H, Wang Z, Tang F, Zhao Y, Feng D, Li Y, Hu Y, Wang C, Zhou J, Tian X, Yao J#. Carnosol-mediated Sirtuin 1 activation inhibits enhancer of Zeste Homolog 2 to attenuate liver fibrosis. Pharmacol Res. 2018, 128:327-337. JCR 1IF:5.574(通讯作者)

(15) Li Z, Wang G, Feng D, Zu G, Li Y, Shi X, Zhao Y, Jing H, Ning S, Le W, Yao J#, Tian X#. Targeting the miR-665-3p-ATG4B-autophagy axis relieves inflammation and apoptosis in intestinal ischemia/reperfusion. Cell Death Dis. 2018, 9(5):483. JCR 1IF:5.959(通讯作者)

(16) Liu L, Yao J#, Li Z, Zu G, Feng D, Li Y, Qasim W, Zhang S, Li T, Zeng H, Tian X#. miR-381-3p knockdown improves intestinal epithelial proliferation and barrier function after intestinal ischemia/reperfusion injury by targeting nurr1. Cell Death Dis. 2018, 9(3):411. JCR 1IF:5.959(通讯作者)

(17) Zhang S, Wang Z, Zhu J, Xu T, Zhao Y, Zhao H, Tang F, Li Z, Zhou J, Gao D, Tian X, Yao J#. Carnosic Acid Alleviates BDL-Induced Liver Fibrosis through miR-29b-3p-Mediated Inhibition of the High-Mobility Group Box 1/Toll-LikeReceptor 4 Signaling Pathway in Rats. Front Pharmacol. 2018, 8:976. JCR 1IF:3.845(通讯作者)

主编教材:

1.《药理学》科学出版社,吴基良、姚继红主编,2020.8

 

联系方式:

 

yaojihong 65@hotmail.com

 

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