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姚继红教授简介

姚继红教授。1988年毕业于中国医科大学临床医疗本科,1988-1991年在大连医科大学获得药理学硕士学位,留校工作至今。2001年获得生物化学专业博士学位。 曾先后在泗川医学奖学金和国家教委留学基金的资助下,赴日本群马大学、美国俄亥俄州立大学作高级访问学者两年。现任大连医科大学药理教研室教授,博士生导师、药学院副院长。多年从事分子药理学的研究。五年来, 共计主持及参加国家及省市各级课题20余项。其中主持国家自然基金2项,国家863子课题1项,国家教育部课题1项,省科技厅项目2项,省教育厅重点实验室项目1项。在国内外知名杂志发表论文50余篇,其中40余篇被SCI收录,4篇被EI收录。获辽宁省科技进步2等奖二项(排名第二),大连市科技进步一等奖2项。发表专著及教材20余部,其中主编3部。

组内研究方向:

(1)急、慢性肝损伤和肝纤维化发生分子机制及药物防治靶点的研究

中药复方及单体的作用机理尤其在分子水平的探讨,有利于传统中药及其活性化学成分的进一步开发和利用,对我国中医药现代化具有战略性意义。本课题组采用多种方法建立急、慢性肝损伤和肝纤维化病理模型,研究其病理生理过程及其相关信号转导通路;研究具有抗氧化、抗炎等作用的天然化合物(如多酚类、黄酮类化合物及某些小分子多肽)的肝保护作用,并深入研究其保护作用的分子机制。如酚酸类化合物对SIRT1、P66等转导通路作用的分子机制,可能成为这些疾病防治的新的药物作用靶点。

(2)天然化合物对药物代谢酶的作用及其转录调控通路的研究

二相药物代谢酶如醌氧化还原酶(NAD(P)H quinone oxidoreductase 1, NQO1)、谷胱甘肽-S-转移酶(glutathione-S-transferase,GST)、血红素加氧酶(heme oxygenase-1,HO-1)等在亲电子试剂和活性氧解毒方面发挥重要的作用,后者又称为二相解毒酶(phase 2 detoxifation enzymes)或二相酶(phase 2 enzymes)。本课题组探讨天然产物如丹参酚酸类、鼠尾草酸等对二相酶的表达及活性影响,通过其上游转录因子如Nrf2/Keap1通路等诱导二相代谢酶的表达在某些氧化损伤性疾病、肿瘤等疾病的防治中发挥重要的作用。

(3) 消化器官缺血再灌注损伤及修复药物防治的分子机制研究。

本研究组近年来在整体及离体模型研究了天然提取物丹参酚酸类、迷迭香二酚类、乌苏里黎卢碱等对NF-KB、泛素蛋白酶体、Nrf2/ARE 、P66、SIRT1等转录因子和信号转导通路的作用,为其应用缺血再灌注损伤等疾病的治疗提供了重要的线索及应用依据。

本课题组研究方向应用分子生物学方法和现代分析技术对药效、药物代谢酶的作用进行深入探讨,有利于丰富中药的研究方法和相关理论,为中医药结合作用于新的药物靶点的治疗提供了实验依据。有助于传统中药及其活性化学成分的进一步开发和利用。

代表性文章:

1. Lin M, Zhai X, Wang G, Tian X, Gao D, Shi L, Wu H, Fan Q, Peng J, Liu K, Yao J.Salvianolic acid B protects against acetaminophen hepatotoxicity by inducing Nrf2 and phase II detoxification gene expression via activation of the PI3K and PKC signaling pathways.J Pharmacol Sci. 2015 Feb;127(2):203-10. (correspondence author,IF: 2.114)

2. Wang G, Chen Z, Zhang F, Jing H, Xu W, Ning S, Li Z, Liu K, Yao J, Tian X.Blockade of PKCβ protects against remote organ injury induced by intestinal ischemia and reperfusion via a p66shc-mediated mitochondrial apoptotic pathway. Apoptosis. 2014 Sep;19(9):1342-53(correspondence author,IF: 3.614)

3. Chen Z, Wang G, Zhai X, Hu Y, Gao D, Ma L, Yao J, Tian X.Selective inhibition of protein kinase C β2 attenuates the adaptor P66 Shc-mediated intestinal ischemia-reperfusion injury.Cell Death Dis. 2014 Apr 10;5:e1164. (correspondence author,IF: 5.177)

4. Yan H, Jihong Y, Feng Z, Xiaomei X, Xiaohan Z, Guangzhi W, Zhenhai M, Dongyan G, Xiaochi M, Qing F, Kexin L, Xiaofeng T.Sirtuin 1-mediated inhibition of p66shc expression alleviates liver ischemia/reperfusion injury.Crit Care Med. 2014 May;42(5):e373-81. (correspondence author,IF: 6.124)

5. Li M, Lu Y, Hu Y, Zhai X, Xu W, Jing H, Tian X, Lin Y, Gao D, Yao J Salvianolic acid B protects against acute ethanol-induced liver injury through SIRT1-mediated deacetylation of p53 in rats.Toxicol Lett. 2014 Apr 21;228(2):67-74.(correspondence author,IF: 3.145)

6. Fan Z, Jing H, Yao J, Li Y, Hu X, Shao H, Shen G, Pan J, Luo F, Tian X.The protective effects of curcumin on experimental acute liver lesion induced by intestinal ischemia-reperfusion through inhibiting the pathway of NF-κB in a rat model.Oxid Med Cell Longev. 2014; 2014:191624. (correspondence author,IF: 3.363)

7.Zhai X, Lin M, Zhang F, Hu Y, Xu X, Li Y, Liu K, Ma X, Tian X, Yao J. Dietary flavonoid genistein induces Nrf2 and phase II detoxification gene expression via ERKs and PKC pathways and protects against oxidative stress in Caco-2 cells. Mol Nutr Food Res. 2013 Feb;57(2):249-59. (IF: 4.301) (correspondence author)

8. Xu X, Hu Y, Zhai X, Lin M, Chen Z, Tian X, Zhang F, Gao D, Ma X, Lv L, Yao J.

Salvianolic acid A preconditioning confers protection against concanavalin A-induced liver injury through SIRT1-mediated repression of p66shc in mice.Toxicol Appl Pharmacol. 2013 Nov 15;273(1):68-76. (correspondence author,IF: 3.975)

9. Wang GZ, Yao JH, Jing HR, Zhang F, Lin MS, Shi L, Wu H, Gao DY, Liu KX, Tian XF. Suppression of the p66shc adapter protein by protocatechuic acid prevents the development of lung injury induced by intestinal ischemia reperfusion in mice. J Trauma Acute Care Surg. 2012 Nov;73(5):1130-7 (IF: 2.478)

10. Jing H, Shen G, Wang G, Zhang F, Li Y, Luo F, Yao J, Tian XF. MG132 Alleviates Liver Injury Induced by Intestinal Ischemia/Reperfusion in Rats: Involvement of the AhR and NFκB Pathways. J Surg Res. 2012;176(1):63-73.(correspondence author) (IF:2.247)

11.Zhu QZ, Yao JH, Wani G, Wani MA & Wani AA. Mdm2 mutant defective in binding p300 promotes ubiquitination but not degradation of p53: evidence for the role of p300 in integrating ubiquitination and proteolysis. J Biol Chem 2001;276:29695-29701 (SCI).

12.Wani MA, Wani G, Yao JH, Zhu QZ. and Wani AA. Human cells deficient in p53 regulated p21 exhibit normal nucleotide excision repair of UV –induced DNA damage. Carcinogenesis 2002;23(3):403-10 (SCI).

13.姚继红,朱千政,崔秀云. 破坏泛素依赖的蛋白水解通路对p53 转录激活的抑制作用.肿瘤防治杂志 2003;10(5):481-484

14. Zhu Q, Yao JH, Wani G, Chen J, Wang QE, Wani AA. The ubiquitin-proteasome pathway is required for the function of the viral VP16 transcriptional activation domain. FEBS Lett 2004;556(1-3):19-25 (SCI).

15.Wang YZ, Han GZ, Yao JH, Su CY. Studies on Pharmacokinetics of rhCNTF in Rats. Asian Journal of Pharmacodynamics and Pharmacokinetics 2006;(1):63-67 (correspondence author)

16.Tian XF, Zhang XS, Li YH, Wang ZZ, Zhang F, Wang LM, Yao JH. Proteasome inhibition attenuates lung injury induced by intestinal ischemia reperfusion in rats. Life Sci 2006;79(22):2069-76 (SCI)(correspondence author)

17. Yuan JC, Han GZ, Yao JH, Li L, Yuan J, Chen X. Simultaneous determination of five water-soluble components of Danshen Injection in rats for multicomponent pharmacokinetic and bioavailability study. DRUG METABOLISM REVIEWS, 40: 189-190 290 Suppl. 2. 2008.(SCI)(correspondence author)

18.Yao JH, Li YH, Wang ZZ, Zhang XS, Wang YZ, Yuan JC, Zhou Q, Liu KX, Tian XF. Proteasome inhibitor lactacystin ablates liver injury induced by intestinal ischaemia-reperfusion. Clin Exp Pharmacol Physiol 2007;34(11):1102-8. (SCI)

19. Wang H, Wang C, Yao J, Liu K. Study on hemostatic mechanism of fully soluble hemostatic fiber. Blood Coagul Fibrinolysis. 2007 Sep;18(6):555-8. (SCI)

20.Wang ZZ, Zhao WJ, Zhang XS, Tian XF, Wang YZ, Zhang F, Yuan JC, Han GZ, Liu KX, Yao JH. Protection of Veratrum nigrum L. var. ussuriense Nakai alkaloids against ischemia-reperfusion injury of the rat liver. World J Gastroenterol 2007;13(4):564-712. (SCI)(correspondence author)

21.Zhu Q, Wani G, Yao J, Patnaik S, Wang QE, El-Mahdy MA, Praetorius-Ibba M, Wani AA. The ubiquitin-proteasome system regulates p53-mediated transcription at p21waf1 promoter. Oncogene 2007;26(29):4199-208 (SCI)

22. Wu J, Yang T, Wang C, Liu Q, Yao J, Sun H, Kaku T, Liu KX.. Laennec protects murine from concanavalin A-induced liver injury through inhibition of inflammatory reactions and hepatocyte apoptosis. Biol Pharm Bull. 2008;31(11):2040-4. (SCI)

23.Jun Yuan, Ji-Hong Yao, Qin Zhou, Xiao-Wei Hu, Liang Chu, Xiao-Feng Tian. Anti-inflammatory activity of Salvianic acid A through the inhibition of nuclear factor-Kappa B activation in peritoneal macrophage. ICBBE 2009. Jun 12, 2009 (EI) (correspondence author)

24.Ji-Hong Yao, Xue-Song Zhang, Shu-Sen Zheng, Li-Ming Wang, Shu Wang, Min Liu, Zhen-Zhen Wang, Ke-Xin Liu, Xiao-Feng Tian. Prophylaxis with carnosol attenuates liver injury induced by intestinal ischemia/reperfusion. World J Gastroenterol 2009; 15(26): 3240-5 (SCI).

25. Tian XF, Yao JH*, Zhang XS, Zheng SS, Guo XH, Wang LM, Wang ZZ, Liu KX. Protective effect of carnosol on lung injury induced by intestinal ischemia/reperfusion. Surg Today. 2010 Sep;40(9):858-65.(SCI)(correspondence author)

26. Zhao HD, Zhang F, Shen G, Li YB, Li YH, Jing HR, Ma LF, Yao JH, Tian XF. Sulforaphane protects liver injury induced by intestinal ischemia reperfusion through Nrf2-ARE pathway.World J Gastroenterol. 2010 Jun 28;16(24):3002-10

27. Li Y, Yao JH*, Hu XW, Fan Z, Huang L, Jing HR, Liu KX, Tian XF. Inhibition of Rho kinase by fasudil hydrochloride attenuates lung injury induced by intestinal ischemia and reperfusion. Life Sci. 2011 Jan 3;88(1-2):104-9. (SCI)(correspondence author)

正在主持的科研项目情况

1)丹酚酸B 激活Nrf2/ARE 通路在对乙酰氨基酚肝损伤中的保护机制研究。国家自然基金(2012-2015.12, 进行中)

2)鼠尾草酸调控miR-34a/SIRT1-p66shc信号通路抗酒精性肝损伤的分子机制研究。 国家自然基金(81473266,2015-2018.12, 进行中)

编辑:王长远 最后更新:2015-5-17 21:26:44

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