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浏览文章 【2014-07-20 14:06:21】  【点击数:】【字号: 】 【我要打印

孙慧君教授简介

孙慧君,女,1966年8月生人,医学博士,药理学教授,博士生导师。1990年毕业于大连医科大学临床医学系,获学士学位;1993年获大连医科大学药理学硕士学位,2001年获大连医科大学病理学博士学位。曾先后三次于日本筑波大学、山梨大学做高级访问学者和工作。主要从事代谢性疾病药理学的研究,在国外著名杂志上发表SCI收录文章50余篇。作为主持人及主要参加人,曾主持及参加多项国家级、省市级及横向科研课题的研究。主编及参编教材20余部,其中规划教材10余部。
近5年发表的通讯作者论文:
1. Dachuan Shena, Lili Tianc, Tingting Shen, Huijun Sun,Pixu Liu. Alpha-Lipoic Acid Protects Human Aortic Endothelial Cells Against H2O2-Induced Injury and Inhibits Atherosclerosis in Ovariectomized Low Density Lipoprotein Receptor Knock-Out Mice. Cell Physiol Biochem  2018 Jul 5;47(6):2261-2277. (IF:5.5)(共同通讯作者)
2. Yukun Zhang , Changyuan Wang, Yue Jin , Qining Yang , Qiang Meng, Qi Liu , Yongguo Dai , Lifei Cai , Zhihao Liu , Kexin Liu, Huijun Sun. Activating the PGC-1α/TERT Pathway by Catalpol Ameliorates Atherosclerosis via Modulating ROS Production, DNA Damage, and Telomere Function: Implications on Mitochondria and Telomere Link. Oxidative Medicine and Cellular Longevity. 2018, ID 2876350. (IF:4.936)(通讯作者)
3. Jiting Yan, Changyuan Wang, Yue Jin, Qiang Meng, Qi Liu, Zhihao Liu,
Kexin Liu, Huijun Sun*. Catalpol ameliorates hepatic insulin resistance in type 2 diabetes through acting on AMPK/NOX4/PI3K/AKT pathway. Pharmacological Research. 2018, 130:466-480(通讯作者)(IF:4.897)(通讯作者)
4. Yukun Zhang, Changyuan Wang, Qining Yang, Yue Jin, Qiang Meng, Qi Liu Ph, Yongguo Dai, Zhihao Liu, Kexin Liu, Huijun Sun.* Catalpol Attenuates Oxidative Stress and Promotes Autophagy in TNF-α-Exposed HAECs through up-regulating AMPK.  RSC Adv. 2017,7, 52561 –52572 (IF: 3.1080)(通讯作者)
5. Shi-Yu Lu, Chang-Yuan Wang, Yue Jin, Qiang Meng, Qi Liu, Zhi-hao Liu, Ke-Xin Liu,Hui-Jun Sun, Mo-Zhen Liu. The osteogenesis-promoting effects of alpha-lipoic acid against glucocorticoid-induced osteoporosis through the NOX4,NF-kappaB, JNK and PI3K/AKT pathways. Sci Rep. 2017 13; 7(1): 3331. (IF: 4.2589)(通讯作者)
6.Jiting Yan, Changyuan Wang, Yue Jin, Qiang Meng, Qi Liu, Zhihao Liu, Kexin Liu.and Huijun Sun*. Catalpol prevents alteration of cholesterol homeostasis in non-alcoholic fatty liver disease via attenuating endoplasmic reticulum stress and NOX4 over-expression. RSC Adv., 2017, 7, 1161. (IF: 3.1080)(通讯作者)
7. Jing Liang, Changyuan Wang, Jinyong Peng, Wenshuang Li, Yue Jin, Qi Liu, Qiang Meng, Kexin Liu, Huijun Sun*. Naringin regulates cholesterol homeostasis and inhibits inflammation via modulating NF-_B and ERK signaling pathways in vitro. Pharmazie, 2016,71: 101–108. (IF: 1.246)(通讯作者)
8. Huimin Hu, Changyuan Wang, Yue Jin, Qiang Meng, Qi Liu, Kexin Liu, Huijun Sun*. Alpha-lipoic acid defends homocysteine-induced endoplasmic reticulum and oxidative stress in HAECs. Biomedicine & Pharmacotherapy, 2016(80):63–722.(IF: 2.326)(通讯作者)
9. Wenshuang Li, Changyuan Wang, Jinyong Peng, Jing Liang, Yue Jin, Qi Liu,Qiang Meng, Kexin Liu and Huijun Sun*. α-lipoic acid protects HAECs from high glucose-induced apoptosis via decreased oxidative stress, ER stress and mitochondrial injury. RSC Adv., 2015, 5, 70726(IF:3.84)(通讯作者)
10. Chao Fu,Dong Xu, Chang-yuan Wang, Yue Jin, Qi Liu, Qiang Meng, Ke-xin Liu, Hui-jun Sun, Mo-zhen Liu. Alpha-LipoicQ1 Acid Promotes Osteoblastic Formation in H2O2-Treated MC3T3-E1 Cells and Prevents Bone Loss in Ovariectomized Rats. J Cell Physiol. 2015,230(9):2184-201. (IF:3.874)(通讯作者)
11. Shan Wu, Hui Xu, Jinyong Peng, Changyuan Wang, Yue Jin, Kexin Liu, Huijun Sun, Jianhua Qin. Potent anti-inflammatory effect of dioscin mediated by suppression of TNF-a-induced VCAM-1, ICAM-1and EL expression via the NF-kB pathway. Biochimie,2015,110:62-72. (IF:3.123)(通讯作者)
12. Jin Yue, Liu Kexin, Peng Jinyong, Wang Changyuan, Kang Li, Chang Ning, Sun Huijun. Rhizoma Dioscoreae Nipponicae polysaccharides protect HUVECs from H2O2-induced injury by regulating PPAR gamma factor and the NADPH oxidase/ROS-NF-kappa B signal pathway. Toxicol Lett, 2015, 232 ( 1): 149-158. (IF:3.355)(通讯作者)
13. Li W, Wang C, Peng J, Liang J, Jin Y, Liu Q, Meng Q, Liu K, Sun H. Naringin inhibits TNF-α induced oxidative stress and inflammatory response in HUVECs via Nox4/NF-κ B and PI3K/Akt pathways. Curr Pharm Biotechnol. 2014, 15(12):1173-82. (IF:2.511)(通讯作者)
14. Xu L, Wang CY, Lv L, Liu KX, Sun HJ, Han GZ. Pharmacokinetics of phosphocreatine and its active metabolite creatine in the mouse plasma and myocardium. Pharmacol Rep. 2014 Oct;66(5):908-14 (IF:2.165)(通讯作者)
15.Chunfang Zhang, Jinyong Peng, Shan Wu, Yue Jin, Fan Xia, Changyuan Wang, Kexin Liu, Huijun Sun, Mozhen Liu. Dioscin promotes osteoblastic proliferation and differentiation via Lrp5 and ER pathway in mouse and human osteoblast-like cell lines. Journal of Biomedical Science 2014 Apr 17;21(1):30. (IF:2.763)(通讯作者)
16. Xia F, Wang C, Jin Y, Liu Q, Meng Q, Liu K, Sun H. Luteolin Protects HUVECs from TNF-α-induced Oxidative Stress and Inflammation via its Effects on the Nox4/ROS-NF-κB and MAPK Pathways. J Atheroscler Thromb. 2014;21(8):768-83.(IF:2.933)(通讯作者)
承担的主要科研课题:
1.国家自然科学基金负责人:木犀草素抑制Nox4/ROS-NF-κB通路抗动脉粥样硬化作用及分子药理学机制研究(81273508),2013 年 01 月至 2016 年 12 月,70万
2.辽宁省科技厅项目负责人:薯蓣皂苷调控衔接蛋白P66Shc抑制动脉粥样硬化血管钙化作用的研究,20180530065,2019.1.1-2020.12.31

 

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