一、个人情况简介
1987.11生，中西医结合基础博士，副教授，现就职于大连医科大学药学院药化教研室。近年来，主持国家自然基金青年基金 1 项，辽宁省博士科研启动 1 项，参与国家重点研发计划子课题一项，参与国家自然基金面上项目7项。在 Sci Adv, Signal Transduct Target Ther，Mol Cancer，J Pineal Res，Bioorg Chem，Anal Chim Acta，Drug Metab Dispos，Am J Cancer Res 等权威期刊，发表多篇科研论文，其中第一及通讯作者 20 余篇，最高影响因子 38.104，研究成果获得辽宁省科学技术进步奖二等奖两次，授权专利 3 项。
研究方向：
· 中药药效物质体内、体外抗肿瘤活性及机制的研究；
· 内源性活性药效物质的肿瘤细胞代谢及其代谢产物活性与机制研究。
二、代表性成果
文章：
1. Wen Zhang, Yulin Peng, Meirong Zhou, Lei Qian, Yilin Che, Junlin Chen, Wenhao Zhang, Chengjian He, Minghang Qi, Xiaohong Shu, Manman Tian, Xiangge Tian, Yan Tian, Sa Deng, Yan Wang, Xiaokui Huo, Zhenlong Yu（通讯）, Xiaochi Ma. RBM14 enhances transcriptional activity of p23 regulating CXCL1 expression to induce lung cancer metastasis. Acta Pharmaceutica Sinica B, 2025; 15 (6): 3059-3072.
2. Huo X, Yu Z(共一), Zhao F, Chen Y, Chen P, Xing L, Qiao Y, Peng Y, Tian M, Zhou M, Wu F, Wang Y, Wang C, Tian X, Lv D, Zhang B, Shi L, Ma X, Ma T. Hepatocyte aquaporin 8-mediated water transport facilitates bile dilution and prevents gallstone formation in mice. J Hepatol. 2025； 82(3):464-479.
3. Zhou M, Wang J, Peng Y, Tian X, Zhang W, Chen J, Wang Y, Wang Y, Yang Y, Zhang Y, Huo X, Wu Y, Yu Z（通讯）, Xie T, Ma X. Elemene as a binding stabilizer of microRNA-145-5p suppresses the growth of non-small cell lung cancer. J Pharm Anal. 2025; 15(3): 101118.
4. Liang J, Tian X, Zhou M, Yan F, Fan J, Qin Y, Chen B, Huo X, Yu Z(通讯), Tian Y, Deng S, Peng Y, Wang Y, Liu B, Ma X. Shikonin and chitosan-silver nanoparticles synergize against triple-negative breast cancer through RIPK3-triggered necroptotic immunogenic cell death. Biomaterials. 2024; 309:122608.
5. Wang M, Pan B, Hu Y, Gao J, Hou L, Yu Z(通讯), Li M, Zhao Z. STIL facilitates the development and malignant progression of triple-negative breast cancer through activation of Fanconi anemia pathway via interacting with KLF16. Transl Oncol. 2024 May 31:46:102010.
6. Yu ZL(一作,通讯), Peng YL, Gao J, Zhou MR, Shi L, Zhao F, Wang C, Tian XG, Feng L, Huo1 XK, Zhang BJ, Liu M, Fang DY, and Ma XC. The p23 cochaperone is a succinate-activated COX-2 transcription factor in lung adenocarcinoma tumorigenesis. Sci Adv. 2023 Jun 30;9(26):eade0387.
7. Yu Z*, Gao J*, Zhang X*, Peng Y*, Wei W, Xu J, Li Z, Wang C, Zhou M, Tian X, Feng L, Huo X, Liu M, Ye M#, Guo DA#, Ma X#. Characterization of a small-molecule inhibitor targeting NEMO/IKKβ to suppress colorectal cancer growth. Signal Transduct Target Ther. 2022, 7(1):71.
8. Liu M*, Peng Y*, Che Y*, Zhou M, Bai Y, Tang W, Huang S, Zhang B, Deng S, Wang C#, Yu Z#. MiR-146b-5p/TRAF6 axis is essential for Ginkgo biloba L. extract GBE to attenuate LPS-induced neuroinflammation. Front Pharmacol. 2022, 13:978587.
9. Yu ZL*, Zhou MR*, Wang WY, Chang YB, Sun CP, Lv X, Wang C, Zhao WY, Ma XC. Cytotoxic diterpenoid dimer containing an intricately caged core from Euphorbia fischeriana. Bioorg Chem. 2022 Jun;123:105759.
10. Yu, ZL(一作), Bai, R, Zhou, JJ, Huang, HL, Zhao, WY, Huo, XK, Yang, YH, Luan, ZL, Zhang, BJ, Sun, CP, Ma, XC. Uncarialins J-M from Uncaria rhynchophylla and Their Anti-depression Mechanism in Unpredictable Chronic Mild Stress-Induced Mice via Activating 5-HT1A Receptor. Chin. J. Chem. 2021, 39, 1331-1343.
11. Yu Z#, Tian X#, Peng Y#, Sun Z, Wang C, Tang N, Li B, Jian Y, Wang W, Huo X and Ma X. Mitochondrial cytochrome P450 (CYP) 1B1 is responsible for melatonin-induced apoptosis in neural cancer cells. J Pineal Res. 2018; 65(1):e12478.
课题：
1. 国家自然科学基金青年基金项目，82004089，基于“阴阳失衡”探讨中药紫草活性成分紫草素阻断IKKβ/NEMO缔合抑制结肠癌微环境炎症的机制研究，主持；
2. 辽宁省自然科学基金博士启动基金计划，2022-BS-253，中药紫草抑制结肠癌炎症反应的作用机制及物质基础研究，主持
三、联系方式
E—mail：qdyuzl871123@163.com
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