一、个人情况介绍
赵妍，女，1987年7月出生，医学博士，现为大连医科大学药学院副教授，硕士研究生导师。研究领域聚焦于肝脏疾病的分子药理学，特别是天然产物的靶点鉴定和作用机制。现任中国药理学会会员、辽宁省免疫学会免疫药学分会第一届专业委员会委员、大连市药学会第十二届理事会药理专业委员会委员。近年来，主持国家自然科学基金项目1项，辽宁省教育厅科研项目1项。辽宁省科技进步二等奖（排名9），辽宁医学会自然科技二等奖（排名7）。以第一作者发表SCI论文8篇，以通讯作者发表3篇。参与教材《药理学》《药物治疗学》《药物学概论》编写。
二、代表性成果
SCI文章
（1）Wang Y, Tian X, Wang Z, Liu D, Zhao X, Sun X, Tu Z, Li Z, Zhao Y#, Zheng S#, Yao J#. A novel peptide encoded by circ-SLC9A6 promotes lipid dyshomeostasis through the regulation of H4K16ac-mediated CD36 transcription in NAFLD. Clin Transl Med. 2024, 14(8):e1801.
（2）Li R, Wang Z, Wang Y, Sun R, Zou B, Tian X, Liu D, Zhao X, Zhou J, Zhao Y#, Yao J#. SIRT3 regulates mitophagy in liver fibrosis through deacetylation of PINK1/NIPSNAP1. J Cell Physiol. 2023, 238(9):2090-2102.
（3）Tian X*, Zhao Y*, Yang Z, Lu Q, Zhou L, Zheng S. USP15 regulates p66Shc stability associated with Drp1 activation in liver ischemia/reperfusion. Cell Death Dis. 2022, 13(9):823.
（4）Geng Y, Wang Y, Sun R, Kang X, Zhao H, Zhu M, Sun Y, Hu Y, Wang Z, Tian X, Zhao Y#, Yao J#.
Carnosol alleviates nonalcoholic fatty liver disease by inhibiting mitochondrial dysfunction and apoptosis through targeting of PRDX3. Toxicol Appl Pharmacol. 2021, 432:115758.
（5）Wang R, Wang Z, Sun R, Fu R, Sun Y, Zhu M, Geng Y, Gao D, Tian X, Zhao Y#, Yao J#. Activation of TAF9 via Danshensu-Induced Upregulation of HDAC1 Expression Alleviates Non-alcoholic Fatty Liver Disease. Front Pharmacol. 2021, 12:775528.
（6）Zhou J*, Zhao Y*, Li Z, Zhu M, Wang Z, Li Y, Xu T, Feng D, Zhang S, Tang F, Yao J.
miR-103a-3p regulates mitophagy in Parkinson's disease through Parkin/Ambra1 signaling.
Pharmacol Res. 2020, 160:105197.
（7）Wang Z*, Zhao Y*, Sun R, Sun Y, Liu D, Lin M, Chen Z, Zhou J, Lv L, Tian X, Yao J. circ-CBFB upregulates p66Shc to perturb mitochondrial dynamics in APAP-induced liver injury. Cell Death Dis. 2020, 11(11):953.
（8）Wang Z*, Zhao Y*, Zhao H, Zhou J, Feng D, Tang F, Li Y, Lv L, Chen Z, Ma X, Tian X, Yao J. Inhibition of p66Shc Oxidative Signaling via CA-Induced Upregulation of miR-203a-3p Alleviates Liver Fibrosis Progression. Mol Ther Nucleic Acids. 2020, 21:751-763.
（9）Zhao Y*, Wang Z*, Zhou J*, Feng D, Li Y, Hu Y, Zhang F, Chen Z, Wang G, Ma X, Tian X, Yao J. LncRNA Mical2/miR-203a-3p sponge participates in epithelial-mesenchymal transition by targeting p66Shc in liver fibrosis. Toxicol Appl Pharmacol. 2020, 403:115125.
（11）Zhao Y*, Wang Z*, Feng D, Zhao H, Lin M, Hu Y, Zhang N, Lv L, Gao Z, Zhai X, Tian X, Yao J. p66Shc Contributes to Liver Fibrosis through the Regulation of Mitochondrial Reactive Oxygen Species. Theranostics. 2019 Feb 20;9(5):1510-1522.
（12）Zhao Y, Shi X, Ding C, Feng D, Li Y, Hu Y, Wang L, Gao D, Tian X, Yao J. Carnosic acid prevents COL1A2 transcription through the reduction of Smad3 acetylation via the AMPKα1/SIRT1 pathway. Toxicol Appl Pharmacol. 2018, 339:172-180.
（13）Shi X*, Zhao Y*, Ding C, Wang Z, Ji A, Li Z, Feng D, Li Y, Gao D, Zhou J, Tian X, Yao J. Salvianolic acid A alleviates chronic ethanol-induced liver injury via promotion of β-catenin nuclear accumulation by restoring SIRT1 in rats. Toxicol Appl Pharmacol. 2018, 350:21-31.
科研项目
（1）国家自然科学基金青年基金项目，82004044，基于 USP15/p66Shc 通路探讨丹参素减轻肝纤维化的作用机制，2021.01-2023.12，主持
（2）辽宁省博士科研启动基金计划项目，2021-BS-216，原儿茶酸调控去泛素化酶USP15 减轻肝纤维化的机制研究，2021.08-2023.07，主持
（3）YTHDF3介导circ-ARHGAP12编码蛋白调控小肠缺血再灌注多器官损伤的机制研究，82172169，国家自然科学基金面上项目，2022.01-2026.12，排名3
三、联系方式
zhaoyan2019@dmu.edu.cn
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