一、个人情况介绍(包括出生年月,学历学位,社会任职,所获奖励,研究方向等个人信息)
张建斌,1985年生,博士,副教授,硕士生导师。入选辽宁省百千万人才工程万层次,大连市青年科技之星,中华中医药学会中成药分会委员,世界中联网络药理学学会理事,《中国临床药理学与治疗学》等杂志青年编委。主要从事口服脂质药物递送系统和天然高分子药物递送系统的研究,先后研制了微乳、脂质体、固体脂质纳米粒、脂质纳米囊、壳聚糖自组装纳米粒、PLGA微球、固体分散体、介孔硅、碳量子点等等多种剂型。先后主持国自然1项、博士后面上基金1项、辽宁省教育厅项目1项、大连市高层次人才项目1项、大连医科大学横向课题1项,累计经费51.7万元,参与各级科研项目10余项。在Acta Pharm Sin B、Mol Pharmaceut、AAPS Pharmscitech、Drug Deliv、Chem Commun、Eur J Pharm Sci等刊物发表SCI论文37篇、中文核心论文5篇。其中第一或通讯作者论文19篇,并有1篇被中国科技期刊卓越行动计划领军期刊Acta Pharm Sin B收录。申请发明专利21项,授权5项。主持中华医学会等教改课题1项、校改课题1项,参编科学出版社规划教材1部、中国医药科技出版社规划教材1部。指导多名学生发表SCI论文、参加大学生创新创业项目并获奖。获得辽宁省教学成果奖三等奖、辽宁省自然科学学术成果奖三等奖。
二、代表性成果(包括文章,课题等)
主持课题:
(1) 中国博士后科学基金面上资助,2021MD703800,基于脂质纳米粒在胃肠道中结构变化及药物释放时空规律指导处方设计以提高药物口服生物利用度的研究,2021/11-2023/04,8万元,在研
(2) 国家自然科学基金青年基金,81903560,超声介导脂质纳米粒克服粘液层和小肠上皮细胞双重屏障及其胃肠道传递过程的研究,2020/01-2022/12,21万元,已结题。
(3) 大连市青年科技之星,2018RQ81,细胞穿膜肽修饰的粘液层渗透型微乳液克服粘液层和小肠上皮细胞双重屏障及其胃肠道传递过程的研究,2019/01-2020/12,10万元,在研。
(4) 辽宁省教育厅科学研究项目一般项目,L2016026,粘液层渗透型微乳液的构建及其提高白藜芦醇口服生物利用度的研究,2016/07-2019/06,2.5万元,已结题。
发表文章
(1) Effect of Lipolysis on Drug Release from Self-microemulsifying Drug Delivery Systems (SMEDDS) with Different Core/Shell Drug Location, AAPS PharmSciTech, 2014, 15(3): 731-40
(2) Influence of Microemulsion-mucin Interaction on the Fate of Microemulsions Diffusing through Pig Gastric Mucin Solutions, Molecular Pharmaceutics, 2015, 12(3): 695-705
(3) Preparation and Optimization Lipid Nanocapsules to Enhance the Antitumor Efficacy of Cisplatin in Hepatocellular Carcinoma HepG2 Cells, AAPS PharmSciTech, 2018, 19(5): 2048-2057
(4) In situ monitoring of the structural change of microemulsions in simulated gastrointestinal conditions by SAXS and FRET, Acta Pharmaceutica Sinica B, 2018, 8(4): 655-665
(5) Improvement of the solubility, photostability, antioxidant activity and UVB photoprotection of trans-resveratrol by essential oil based microemulsions for topical application, Journal of Drug Delivery Science and Technology, 2018, 48: 346-354
(6) Facile synthesis of fluorescent carbon dots from Prunus cerasifera fruits for fluorescent ink, Fe3+ ion detection and cell imaging, Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2019, 213: 281-287
(7) Preparation and application of carbon dots derived from cherry blossom flowers, Chemical Physics Letters, 2019, 731: 136586
(8) Phosphocreatine Improves Cardiac Dysfunction by Normalizing Mitochondrial Respiratory Function through JAK2_STAT3 Signaling Pathway In Vivo and In Vitro, Oxidative Medicine and Cellular Longevity, 2019, 6521218
(9) In vitro and in vivo evaluation of self-assembled chitosan nanoparticles selectively overcoming hepatocellular carcinoma via asialoglycoprotein receptor, Drug Delivery, 2021, 28:1, 2071-2084
(10) Green synthesis of carbon dots from elm seeds via hydrothermal method for Fe3+ detection and cell imaging, Inorganic Chemistry Communications, 2022, 144:109837
三、联系方式
邮箱:zhangjb422@163.com