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浏览文章 【2020-05-19 09:29:07】  【点击数:】【字号: 】 【我要打印

孙成鹏 教授简介


 

孙成鹏,博士,教授,硕士研究生导师,任教于大连医科大学药学院药物化学教研室,担任天然药物化学课程任课教师。从事“靶标”驱动的中药药效物质与分子机制研究,以第一或通讯作者在ACS Cent. Sci.、PNAS、Acta Pharm. Sin. B、Int. J. Biol. Sci.、J. Med. Chem.、等期刊发表SCI科研论文70余篇,其中4篇IF > 10,18篇IF > 7。主持国家自然科学基金2项,省市课题2项,入选中华中医药学会青年人才托举工程项目,授权发明专利9项,参编教材3部。获辽宁省科技进步二等奖和大连市科技之星称号。担任世界中医药联合会-中药化学专业委员会理事、中国仪器仪表学会药物质量分析与过程控制分会理事和大连市药学会天然药物专业委员会委员;担任Front. Chem.客座编辑;担任Anal. Chim. Acta、J. Agric. Food Chem.等期刊特约审稿人;担任Acta Materia Medica和沈阳药科大学学报青年编委

主要研究方向:

(1)中药药效物质

(2)可溶性环氧化物水解酶抑制剂的发现及其在神经退行性疾病中的应用

(3)中药活性分子的作用靶标与作用机制

联系方式:suncp146@163.com

近年发表的科研论文:

1. Macrophage inactivation by small molecule wedelolactone via targeting sEH for the treatment of LPS-induced acute lung injury. ACS Cent. Sci., 2023, https://doi.org/10.1021/acscentsci.2c01424. (通讯作者,IF=18.728)

2. Kurarinone alleviated Parkinson's disease via stabilization of epoxyeicosatrienoic acids in animal model. PNAS, 2022, 119, 9, e2118818119. (第一作者,IF= 12.779)

3. Direct targeting of sEH with alisol B alleviated the apoptosis, inflammation, and oxidative stress in cisplatin-induced acute kidney injury. Int. J. Biol. Sci., 2023, 19, 294-310. (通讯作者,IF=10.750)

4. Correlation analysis between the chemical contents and bioactivity for the quality control of Alismatis Rhizoma. Acta Pharm. Sin. B, 2018, 8, 242-251. (共同第一作者,IF=14.903)

5. Octacyclic and decacyclic ent-abietane dimers with cytotoxic activity from Euphorbia fischeriana steud. Chinese Chem. Lett., 2022, 33, 4261-4263. (通讯作者,IF= 8.455)

6. Discovery of soluble epoxide hydrolase inhibitors from chemical synthesis and natural products. J. Med. Chem. 2021, 64, 184-215. (第一作者,IF=8.039)

7. Investigation of the inhibitory effect of protostanes on human carboxylesterase 2 and their interaction: Inhibition kinetics and molecular stimulations. Int. J. Biol. Macromol., 2021, 167, 1262–1272. (通讯作者,IF= 8.025)

8. Natural soluble epoxide hydrolase inhibitors from Alisma orientale and their potential mechanism with soluble epoxide hydrolase. Int. J. Biol. Macromol., 2021, 183, 811-817. (通讯作者,IF= 8.025)

9. Natural soluble epoxide hydrolase inhibitors from Inula helenium and their interactions with soluble epoxide hydrolase. Int. J. Biol. Macromol., 2020, 158, 1362-1368. (通讯作者,IF= 8.025)

10. Alismanin A, a triterpenoid with a C34 skeleton from Alisma orientale as a natural agonist of human pregnane X receptor. Org. Lett., 2017, 19, 5645-5648. (通讯作者,IF= 6.492)

 

 

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