孙慧君，女，1966年8月出生，医学博士，药理学教授，博士生导师，辽宁省教学名师，临床药理教研室主任。辽宁省药代动力学与药物转运重点实验室主任。担任中国药理学会教学与科普专业委员会常务委员、中国药理学会麻醉药理专业委员会委员辽宁省药学会药理专业委员会委员等职。曾先后三次于日本筑波大学、山梨大学做高级访问学者和工作。主要从事代谢性疾病药理学及分子药理学的研究，研究中药及其单体在动脉粥样硬化、高脂血症、糖尿病及骨质疏松等代谢性疾病中药理作用及机制，为中药及其单体用于上述疾病的治疗提供了重要的线索及理论依据。先后于国外著名杂志上发表SCI收录文章百余篇。培养博士及硕士研究生近50名。为2022年辽宁省首届优秀研究生导师团队成员。主编及参编教材20余部，其中规划教材20余部。曾主持及完成十余项国家级、省市级及横向科研课题的研究。
近5年发表的通讯作者论文：
1. Meng Meng, Jialin Yao, Yukun Zhang, Huijun Sun, and Mozhen Liu. Potential Anti-Rheumatoid Arthritis Activities and Mechanisms of Ganoderma lucidum Polysaccharides. Molecules. 2023, 28, 2483.
2. Hao Li, Changyuan Wang, Yue Jin, Yuanqing Cai, Jialin Yao, Qiang Meng, Jingjing Wu, Huihan Wang, Huijun Sun, Mozhen Liu. Anti-Postmenopausal osteoporosis effects of Isopsoralen: A bioinformatics-integrated experimental study. Phytotherapy Research. 2022;1–21.
3. Zhang, Jianbin; Zheng, Guoshuang; Tian, Yan; Zhang, Chenghong; Wang, Yuting; Liu, Mingjie; Ren, Dongze; Sun, Huijun; Yu, Weiting. Inorganic chemistry communications, 2022, OCT; 144 .
4. Hao Li , ChangyuanWang, Yue Jin, Yuanqing Cai, Huijun Sun，Mozhen Liu.The integrative analysis of competitive endogenous RNA regulatory networks in osteoporosis. Scientific reports, 2022,12:9549
5. Ruoxi Liao , Mingyuan He, Donghong Hu, Chengzheng Gong, Huiying Du, Hairuo Lin, Huijun Sun. Generation and Characterization of Right Ventricular Myocardial Infarction induced by Permanent Ligation of the Right Coronary Artery in Mice. J. Vis. Exp. 2022, e63508, doi: 10.3791/63508.
6.Ruoxi Liao, Zhihong Li, Qiancheng Wang, Hairuo Lin, Huijun Sun. Revascularization of chronic total occlusion coronary artery and cardiac regeneration. Front. Cardiovasc. Med. 2022, 9:940808. doi: 10.3389/fcvm.
7. Zheng Jing , Changyuan Wang , Shijie Wen , Yue Jin , Qiang Meng , Qi Liu , Jingjing Wu , Huijun Sun, Mozhen Liu . Phosphocreatine Promotes Osteoblastic Activities in H2O2-induced MC3T3-E1 Cells by Regulating SIRT1/FOXO1/PGC-1α Signaling Pathway. Curr Pharm Biotechnol. 2021; 22(5):609-621
8. Tianqi Xie, Changyuan Wang, Yue Jin, Qiang Meng, Qi Liu, Jingjing Wu, Huijun Sun. CoenzymeQ10-induced activation of AMPK-YAP-OPA1 pathway alleviates atherosclerosis by improving mitochondrial function, inhibiting oxidative stress and promoting energy metabolism. Front Pharmacol. 2020 Jul 22; 11:1034.
9. Zhang Y, Wang C, Lu J, Jin Y, Xu C, Meng Q, Liu Q, Dong D, Ma X, Liu K, Sun H. Targeting of miR-96-5p by catalpol ameliorates oxidative stress and hepatic steatosis in LDLr-/- mice via p66shc/cytochrome C cascade. Aging (Albany NY). 2020, 12(3): 2049-2069.
10. Qining Yang, Changyuan Wang, Yue Jin, Xiaodong Ma, Tianqi Xie, Jiaying Wang, Kexin Liu, Huijun Sun. Disocin prevents postmenopausal atherosclerosis in ovariectomized LDLR-/mice through a PGC-1α/ERα pathway leading to promotion of autophagy and inhibition of oxidative stress, inflammation and apoptosis. Pharmacological Research 148 (2019) 104414.
11. Dachuan Shena, Lili Tianc, Tingting Shen, Huijun Sun, Pixu Liu. Alpha-Lipoic Acid Protects Human Aortic Endothelial Cells Against H2O2-Induced Injury and Inhibits Atherosclerosis in Ovariectomized Low Density Lipoprotein Receptor Knock-Out Mice. Cell Physiol Biochem 2018 Jul 5;47(6):2261-2277.
12. Zheng Jing, Changyuan Wang, Qining Yang, Xuelian Wei, Yue Jin, Qiang Meng, Qi Liu, Zhihao Liu, Xiaodong Ma, Kexin Liu, Huijun Sun, Mozhen Liu. Luteolin attenuates glucocorticoid induced osteoporosis by regulating ERK/Lrp‐5/GSK‐3βsignaling pathway in vivo and in vitro. J Cell Physiol. 2018;1–19.
13. Huimin Hu, Changyuan Wang, Yue Jin, Qiang Meng, Qi Liu, Zhihao Liu, Kexin Liu, Xiaoyu Liu, and Huijun Sun. Catalpol Inhibits Homocysteine-induced Oxidation and Inflammation via Inhibiting Nox4/NF-κB and GRP78/ PERK Pathways in Human Aorta Endothelial Cells. Inflammation, 2018, DOI: 10.1007/s10753-018-0873-9.
14. Yukun Zhang , Changyuan Wang, Yue Jin , Qining Yang , Qiang Meng, Qi Liu , Yongguo Dai , Lifei Cai , Zhihao Liu , Kexin Liu, Huijun Sun. Activating the PGC-1α/TERT Pathway by Catalpol Ameliorates Atherosclerosis via Modulating ROS Production, DNA Damage, and Telomere Function: Implications on Mitochondria and Telomere Link. Oxidative Medicine and Cellular Longevity. 2018, 2876350.
15. Jiting Yan, Changyuan Wang, Yue Jin, Qiang Meng, Qi Liu, Zhihao Liu,
Kexin Liu, Huijun Sun. Catalpol ameliorates hepatic insulin resistance in type 2 diabetes through acting on AMPK/NOX4/PI3K/AKT pathway. Pharmacological Research. 2018, 130:466-480
16. Yukun Zhang, Changyuan Wang, Qining Yang, Yue Jin, Qiang Meng, Qi Liu Ph, Yongguo Dai, Zhihao Liu, Kexin Liu, Huijun Sun. Catalpol Attenuates Oxidative Stress and Promotes Autophagy in TNF-α-Exposed HAECs through up-regulating AMPK. RSC Adv. 2017,7, 52561 –52572
17. Shi-Yu Lu, Chang-Yuan Wang, Yue Jin, Qiang Meng, Qi Liu, Zhi-hao Liu, Ke-Xin Liu,Hui-Jun Sun, Mo-Zhen Liu. The osteogenesis-promoting effects of alpha-lipoic acid against glucocorticoid-induced osteoporosis through the NOX4,NF-kappaB, JNK and PI3K/AKT pathways. Sci Rep. 2017 13; 7(1): 3331.
18．Jiting Yan, Changyuan Wang, Yue Jin, Qiang Meng, Qi Liu, Zhihao Liu, Kexin Liu.and Huijun Sun. Catalpol prevents alteration of cholesterol homeostasis in non-alcoholic fatty liver disease via attenuating endoplasmic reticulum stress and NOX4 over-expression. RSC Adv., 2017, 7, 1161.
近5年承担的省部级以上科研课题：
1.国家自然科学基金负责人：circ-CADPS2在高血压促进动脉粥样硬化斑块易损过程中的作用和机制研究, 82073851. 2021.01-2024.12
2. 国家自然科学基金负责人：木犀草素抑制Nox4/ROS-NF-κB 通路抗动脉粥样硬化作用及分子药理学机制研究,81273508，2013.01-2016.12.
3. 辽宁省科技厅项目负责人：薯蓣皂苷调控衔接蛋白P66Shc抑制动脉粥样硬化血管钙化作用的研究，20180530065，2019.1.1-2020.12.31.
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