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浏览文章 【2015-05-17 22:24:06】  【点击数:】【字号: 】 【我要打印

马骁驰教授简介

马 骁 驰 ,博士,教授,博士生导师。天然药物化学专业博士。2008年人才引进至大连医科大学药学院工作。近5年来发表第一(通讯)作者SCI论文40余篇,申请专利4项,授权2项。主持国家自然科学基金4项(青年1项;面上2项,联合主持1项国家自然基金地区基金),主持省市级课题5项,此外主持横向课题10项。参与10余部中药相关领域的规划教材的编写,其中副主编2部。辽宁省自然科学学术成果二等奖2项,第八届辽宁省优秀青年科技奖,辽宁 “百千万人才工程” ,获辽宁省科技进步二等奖2项(参与)。中国科学院药物研发中的早期ADME/T研究技培训专家。世界中医药联合会-中药分析专业委员会理事,中药化学专业委员会理事。国家自然科学基金、北京市自然科学基金、辽宁省自然科学基金评审专家。同时担任国际期刊Global Journal of Analytical Chemistry编委, Biochemical Systematics and Ecology, Journal of Chromatography A, J. Mol.Cata. B, Journal of separation science, Separation and Purification Technology, Analytical Methods及Magnetic Resonance in Chemistry等等诸多国际期刊特约审稿人。

研究方向

1. 活性天然药物和中药复方的体内作用物质基础研究

2. 中药活性成分的生物转化、体内代谢。

3. 中药抗肿瘤和抗纤维化作用机制。

在研项目

1. 国家自然科学基金面上项目“基于代谢特点蟾蜍甾烯类成分的结构与活性、毒性和稳定性之间的关系研究”,项目负责人

2. 国家自然科学基金“壮药排钱草的抗肝纤维化的活性成分、构效关系和作用机制研究”,联合项目负责人

代表性文章(* 通讯作者)

1. Xiangge Tian, Sicheng Liang, Chao Wang, Baojian Wu, Guangbo Ge, Sa Deng, Kexin Liu, Ling Yang and Xiaochi Ma*. Regioselective Glucuronidation of Andrographolide and Its Major Derivatives: Metabolite Identification, Isozyme Contribution, and Species Differences. The AAPS Journal. 2015, 17(1), 156-166 (SCI, 3.91)

2. Zhenlong Yu, Wei Guo, Xiaochi Ma*, Baojing Zhang, Peipei Dong, Lin Huang, Xiuli Wang, Chao Wang, Xiaokui Huo, Wendan Yu, Canhui Yi, Yao Xiao, Wenjing Yang, Yu Qin, Yuhui Yuan, Songshu Meng, Quentin Liu, Wuguo Deng*. Gamabufotalin, a bufadienolide compound from toad venom, suppresses COX-2 expression through targeting IKKbeta/NF-kappaB signaling pathway in lung cancer cells. Molecular Cancer. 2014, 13: 203. (SCI, 5.41)

3. Xia Lv, Dan Liu, Jie Hou, Peipei Dong, Libin Zhan, Li Wang, Sa Deng, Changyuan Wang, Jihou Yao, Xiaohong Shu, Kexin Liu, Xiaochi Ma*. Biotransformation of imperatorin by Penicillium janthinellum. Anti-osteoporosis activities of its metabolites. Food Chemistry. 138 (2013) 2260–2266. (SCI, 3.4)

4. Yan Sun, Dan Liu, RongGang Xi, Xiaobo Wang, Yan Wang, Jie Hou, Baojing Zhang, Changyuan Wang, Kexin Liu, Xiaochi Ma*. Microbial transformation of acetyl-11-keto-β-boswellic acid and their inhibitory activity on LPS-induced NO production. Bioorg Med Chem Lett. 2013, 23(5), 1338-42. (SCI, 2.34)

5. X. Lv, C.-Y. Wang, J. Hou, B.-J. Zhang, S. Deng, Y. Tian, S.-S. Huang, H.-L. Zhang, X.-H. Shu, Y.-H. Zhen, K.-X. Liu, J.-H. Yao, and Xiaochi Ma*. Isolation and identification of metabolites of osthole in rats. Xenobiotica. 2012, 42(11), 1120-7. (SCI, 2.8)

6. Sa Deng, Bao Jing Zhang, Chang Yuan Wang, Yan Tian, Ji Hong Yao, Lei An, Shan Shan Huang, Jin Yong Peng, Ke Xin Liu, Xiaochi Ma*. Microbial transformation of deoxyandrographolide and their inhibitory activity on LPS-induced NO production in RAW 264.7 macrophages. Bioorg Med Chem Lett. 2012, 22(4), 1615-8. (SCI, 2.7)

7. Xiao-Chi Ma, Jing Ning, Guang-Bo Ge, Si-Cheng Liang, Xiu-Li Wang, Bao-Jing Zhang, Shan-Shan Huang, Jing-Kui Li, and Ling Yang*. Comparative Metabolism of Cinobufagin in Liver Microsomes from Mouse, Rat, Dog, Pig, Monkey and Human. Drug Metabolism and Disposition. 2011. 39(4): 675-682 (SCI, 3.73)

8. J. Ning T.-H. Wu, Y. Tian, C.-Y. Wang, G. Tian, B.-J. Zhang, K.-X. Liu, and Xiaochi Ma*. Identification of cinobufagin metabolites in the bile of rats. Xenobiotica. 2010, 40(1), 48-54. (SCI, 2.8)

9. Jingkui Li, Xiaochi Ma*, Fengyun Li, Jingkui Wang, Huirong Chen, Gang Wang, Xia Lv, Changkai Sun, Jingming Jia. Preparative separation and purification of bufadienolides from Chinese traditional medicine of ChanSu using high-speed counter-current chromatography. J Sep Sci. 2010, 33(9), 1325-30. (SCI, 2.63)

10. Feng-Yun Li, Zhan-Ping Gou, Xiaochi Ma*, Yan Tian, Ge Tian, Chang-Yuan Wang, Dong-Hai Su, Ke Xin Liu, Xiu-Lan Xin*. Preparative Isolation and Purification of Two Phenylpropanoids from Daphne giraldii Nitsche by HSCCC. Chromatographia. 2010, 71, 481-485. (SCI, 1.1)

编辑:王长远 最后更新:2015-5-17 22:24:31

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